Epithelial cell adhesion molecule and tumor

Epithelial cell adhesion molecules (EpCAMs) play an important role in the process of gene expression and regulation by combining with nuclear receptor.Aberrant expression of EpCAMs has been detected in different types of cancers,such as breast cancer,lung cancer,gastric cancer,and etc.The research of EpCAMs in circulating tumor cells enrichment,tumor pathogenesis and prognosis will be conducive to achieve new breakthroughs in cancer targeted therapy. Key words: Neoplasms; Antibodies; Therapy; EpCAM