Ameloblastoma of the Mandible With Intracranial Metastasis: A Case Study

• Ameloblastoma is an aggressive locally recurring neoplasm of odontogenic epithelium. We describe a case of a mandibular ameloblastoma with a 17-year history of local recurrences followed by two metachronous intracranial metastases. Central nervous system metastasis without pulmonary involvement is previously unreported in a living patient with ameloblastoma. The behavior of this tumor qualifies it as a malignant ameloblastoma. ( Arch Otolaryngol Head Neck Surg . 1992;118:861-863)