Advance of Glucosamine and Their Derivatives as Chiral Ligands in Asymmetric Syntheses

Glucosamine is a chiral compound degraded from widely existed natural product chitosan. It is becoming an ideal raw material for preparation chiral amine, amine/phosphine ligands due to its more chiral centers and strong coordination ability. The application of glucosamine derivatives as chiral ligands in asymmetric organic reactions has become a very active research area. In this paper, the application of glucosamine derivatives in asymmetric allylic alkylation, Heck reaction, 1,4conjugate addition reaction, epoxidation reaction of olefins and cyclopropanation of olefin has been reviewed.