Environmentally benign synthesis of fluorinated pyrazolone derivatives and their antimicrobial activity

Various fluorine containing 4-[-3-(4-aryl)-1-phenyl-1H-pyrazol-4-yl)methylene]-3-(trifluoromethyl)-1-phenyl-1H-pyrazol-5(4H)-one 3a-g and 3-(trifluoromethyl)-4-(4-oxo-4H-chromon-3-yl)methylene-1-phenyl-1H-pyrazol-5(4H)-one 5;i-k have been synthesized by conventional and non-conventional method. The synthesis 3 and 5 highlights a comparative study of conventional, ultrasonication and microwave techniques. All products have been characterized by IR, 1 H NMR, MS study aid screened for their antimicrobial activity.