Hubungan Nilai Carcinoembryonic Antigen dengan Kejadian Metastasis Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado

Abstract : Carcinoembryonic antigen (CEA) is a tumor marker which has been used worldwide as an indicator of recurrency after treatment and prognosis but not for preoperative diagnosis. This study was aimed to obtain the correlation between CEA level and the metastasis of colorectal cancer. This was an analytical correlational study. Population and samples were patients with colorectal cancer that fulfilled the inclusion criteria at Prof. Dr. R. D. Kandou Hospital Manado from January 2015 through December 2016. Data were analyzed with point-biserial correlation coefficient. There were 55 patients with colorectal cancer in this study. The incidence of colorectal cancer was higher in 2016 (37 patients). Most of them were males (63.3%), had colorectal cancer in the rectum (47.3%), and CEA level above normal (98.1%). As many as 36 patients with CEA level above normal had no metastasis. Of 18 patients with metastasis, the most were in liver, followed by lungs and bones. There were 9 patients with CEA level >1000 μg/dl; all had metastasis. The statistical analysis showed a rpb of 0.634 (P 1000 μg/dl; kesemuanya mengalami metastasis. Uji statistik mendapatkan rpb = 0,634 dengan P < 0,01. Nilai rerata CEA pada pasien dengan metastasis jauh lebih tinggi (541,82 μg) dibandingkan dengan nilai rerata pada pasien tanpa metastasis (60,19 μg). Simpulan: Terdapat hubungan yang kuat dan bermakna antara CEA dengan metastasis. Kata kunci : karsinoma kolorektal, carcinoembryonic antigen (CEA), metastasis