Experimental and clinical validation of plasmadynamic therapy of wounds with nitric oxide

Pronounced wound-healing effect of exogenous nitric oxide obtained by the plasma chemical method was confirmed in rats with aseptic and infected wounds and in patients with complicated stubborn wounds, postradiation and trophic ulcers, necroses of transplanted skin flaps, etc. Morphological study revealed normalization of microcirculation, decreased inflammation, enhanced phagocytosis, activation of macrophages, and accelerated proliferation of fibroblasts.