Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Abstract In this study, we have designed, synthesized and full characterized a novel biological based acidic nano organocatalyst via condensations reaction of uric acid and phosphorous acid. The obtained compound was named theacrine tetrakis(phosphonic acid) (TTPA) and prepared under refluxing ethanol. This new nano organocatalyst was applied as an efficient and recyclable catalyst for the preparation of novel pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation with good to excellent yields.