Gallstones: An Undescribed Cause of Severe Hepatitis

patients needed to use of GCSF or erythropoietin, but all cases could sustain the combination therapy. Three cases had accomplished the combination treatment and showed sustained virological response. Discussion: FLV and other statins (HMG-CoA reductase inhibitors) are reported to have some anti-HCV effects and to enhance the anti-HCV effect of interferon In Vitro. But there are only few clinical studies. This is the first clinical trial of statin, PEGIFN and RBV combination treatment to children and adolescents with CHC. FLV improved the effectiveness of PEG-IFN and RBV dramatically, and disappearance of HCV-RNA was achieved in all 6 patients with treatment resistant CHC. Conclusion: The combination therapy of PEG-IFN, RBV plus FLV was quite effective to CHC in children and adolescents who had not respond to the standard treatment of PEG-IFN and RBV.