Prototype of a Wireless System for Electrical Impedance Spectroscopy:Demonstration of Real Time Measurements on Cells and Biological Medium

A wireless and portable system, consisting in an electronic board and a computer software graphical interface, is presented as a feasible way to do electrochemical impedance spectroscopy of cells and biological medium. It is designed to work inside a culture chamber performing impedance measurement in the frequency range of 64Hz to 200KHz. The board is equipped with a Bluetooth Low Energy (BLE) module allowing it to be wirelessly controlled. The software interface (also called ISMI) is coded with all required functionalities to manage the parameters of the board such as start frequency and sweep, measuring intervals, data acquisition and visualization and also a function to perform automatic measuring between desired time intervals during whole day for many days. A validation of the system shows an average error of about 1.9% and a measuring test of human fibroblast cells shows a good performance of the system. The proposed system is an introductory step in the study of cells related to fibrous tissue induced by implants showing to be a viable and reproducibility-improving approach for such analysis.