Kepatuhan Konsumsi Obat Kelasi Besi dan Kadar Serum Feritin Pasien Talasemia Beta-Mayor di RSUD Al-Ihsan Bandung

Abstract. High serum ferritin levels in thalassemia patients cause various complications that reduce the quality of life of patients. These levels are influenced by various things, one of which is patient compliance in consuming iron chelation. This study aims to determine the level of compliance with iron chelation drug consumption and serum ferritin levels in patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung and the relationship between the two. This is a cross-sectional study involving 50 thalassemia patients at Al-Ihsan Regional Hospital Bandung, which was chosen consecutively. We measure the adherence by the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, filled out with the researcher's guidance, while ferritin level data was obtained from the patient's medical record. Data was collected in July-September 2019, and data were analyzed using chi-square test with the help of STATA software version 13. The results showed the majority of patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung (60%, IK 45.4% - 72.9%) have a low level of compliance in the consumption of iron chelation drugs and most have serum ferritin levels> 2500 ng / ml (58%, IK 43.5% - 71.2%). There was a statistically significant relationship between the level of compliance with iron chelation drug consumption with serum ferritin levels in patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung p = 0.00 (p 2500 ng/ml (58%, IK 43.5% - 71.2%). Terdapat hubungan bermakna secara statistik antara tingkat kepatuhan konsumsi obat kelasi besi dengan kadar serum feritin pada penderita talasemia beta-mayor di RSUD Al-Ihsan Bandung p=0.00( p<0.05). Kata kunci: Feritin, Kepatuhan minum obat, MMAS-8, Talasemia β mayor