Synthesis, spectroscopic and biological study of 3-(furan-2-yl)- [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives

A novel heterocyclic compounds N-(benzo[d]thiazol-2-yl)-2-(3-(furan- 2-yl)-[1,2,4] triazolo [3,4-b][1,3,4]thiadiazol-6-yl)benzamide derivatives 5a–g have been synthesized by the reaction of 4-amino-5-(furan-4-yl)- 4H-1,2,4-triazole-3-thiol 3 and 2-(benzo[d]thiazol-2-ylcarbamoyl) benzoic acid derivatives 4a–g. All the Synthesized compounds were characterized by elemental analysis, 1HNMR, 13CNMR, FT–IR and LC-MS spectral studies. Antibacterial activities were studied against gram positive and gram negative bacteria and antifungal activities of all the compounds were studied against various fungi.