Synthesis of 14C‐labelled satigrel
1996
14 C-Labelled satigrel, or 4-cyano-5-(4'-methoxy [ring-U- 14 C] phenyl)-5-(4-methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4, 4'-dimethoxy [ring-U- 14 C] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 μCi)/mg and 98.8%, respectively.
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