Antioxidant and intestinal recovery function of condensed tannins in Lateolabrax maculatus responded to in vivo and in vitro oxidative stress

Abstract Condensed tannins (CT) were demonstrated to mitigate oxidative stress and maintain intestinal health of fish, but little information is available to clarify the underlying regulation mechanisms. This study was conducted to evaluate the effects of CT supplementation on growth, antioxidant capacity and intestinal barrier function of Lateolabrax maculatus via in vivo oxidized fish oil-induced and in vitro hydrogen peroxide-induced stress models. Results indicated that dietary inclusion of 0.1% CT mitigated oxidative injure and intestinal damage caused by oxidized fish oil as reflected by the recovery of growth performance, serum antioxidant capacity, intestinal permeability and tight junction proteins gene expression. Supplementation of 800 μmol/L of CT in the L. maculatus intestinal epithelial cells damage induced by hydrogen peroxide as in vitro model increased (P