A New Synthesis of Phosphoramidates: Inhibitors of the Key Bacterial Enzyme Aspartate Semi-Aldehyde Dehydrogenase.

A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2in situ—the methodology is especially suited to acid sensitive systems featuring BOC, tBu or acetal protecting groups.