Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling

Baochi Ou,Hongze Sun,Jingkun Zhao,Zhuoqing Xu,Yuan Liu,Hao Feng,Zhihai Peng

Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling

2019

Baochi Ou
Hongze Sun
Jingkun Zhao
Zhuoqing Xu
Yuan Liu
Hao Feng
Zhihai Peng

Background Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role of PLK3 in colorectal cancer (CRC) progression and glucose metabolism remains to be known.

Keywords:

Colorectal cancer
Cancer research
Polo-like kinase
PLK3
STAT3
Hsp90
Suppressor
Kinase
Biology
Carbohydrate metabolism
Signal transduction
Heat shock protein
Glucose uptake
Downregulation and upregulation
microRNA
Chromatin immunoprecipitation

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