1,6 Addition of carbanionic reagents to 10-methyl hexahydronaphthalenone

Abstract 1,6 addition of carbanionic reagents to bicyclic dienone 1 requires anionic activation : according to the acidity of the corresponding carbon acids, good yields in 7α -adducts can be obtained either in THF-HMPA with nBuLi or tBuOK as bases or under solid-liquid phase transfer catalysis.