Clinical and immunologic effects of maraviroc in progressive multifocal leukoencephalopathy.

Progressive multifocal leukoencephalopathy (PML) is a rare but generally fatal disease due to JC virus (JCV) reactivation, mainly occurring in immunosuppressed patients.1 Therapeutic options are limited to blocking glial cell infection by mirtazapine or restoring cell-mediated immunity to acquire viral control.2