세포투과 펩티드를 함유한 고분자 미셀 및 리포좀을 이용한 배나무 잎 추출물의 피부 흡수 증진

Antioxidant, antibacterial, and skin penetration tests were conducted to investigate the skin absorption of Pyrus serotina var leaf extracts using polymer micelles and their applicability to cosmetic ingredients. Total polyphenol content was found to be 118.83 ± 9.39 mg/g in Pyrus serotina var leaf ethanol extract and 106.89 ± 4.45 mg/g in Pyrus serotina var leaf hydrothermal extract. The DPPH radical scavenging activity was found to be the highest radical scavenging activity of 74.39 ± 7.48% of the Pyrus serotina var leaf ethanol extract at the concentration of 500 mg/L. The SOD-like activity was 91.62 ± 0.43%, the highest value at the concentration of 1,000 mg/L in the hydrothermal extract. After the experiment, antioxidation, wrinkle improvement and whitening activity were confirmed, and the Pyrus serotina var leaf extract was highly likely to be realized as antioxidant and antibacterial material. In the skin penetration experiment with the Pyrus serotina var leaf ethanol extract, the permeation amount of total accumulated tannic acid was found to be Formulation 2 (55.45 μg/cm²), Formulation 1 (46.43 μg/cm²), Formulation 0 (34.36 μg/cm²). In the liposome’s skin penetration experiment containing pear leaf hydrothemal extract, the total amount of accumulated tannic acid permeation was found to be Formulation 5 (75.01 μg/cm²), Formulation 4 (64.01 μg/cm²) and Formulation 3 (36.60 μg/cm²). Through this study, we confirmed the possibility of antioxidant and wrinkle effects of Pyrus serotina var leaf extract. In addition, as a result of skin penetration through the production of polymer micelles and liposome containing Pyrus serotina var leaf extract, It will be more usable in cosmetic industry.