Synthesis of 4-oxo-1,4,5,6,7,8-hexahydro-1H-pyrazolo[3,4-e]-[1,4]diazepine-7-carbonitriles, -carboxamides, and -carboxylic acids
2014
Products of intramolecular cyclocondensation of 5-amino-N-(2,2-dimethoxyethyl)pyrazolo-4-carboxamides, 7-hydroxy-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones, react with potassium cyanide in water affording 4-oxo-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepine-7-carbonitriles, which under the conditions of alkaline hydrolysis are converted into the corresponding carboxamides and carboxylic acids.
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