Pharmacokinetic studies of Tegaserod Maleate Tablet in healthy volunteers

OBJECTIVE Pharmacokinetic characteristics of the single dose and multidose of Tegaserol were evaluated in Chinese healthy volunteers.METHODS The concerntrations of Tegaserod in plasma were determined by LC-MS method and its pharmacokinetic parameters were calculated.RESULTS and CONCLUSION The LC-MS method is sensitive and suitable to Tegaserol human pharmacokinetic studies.The recovery rate and variations of within day and between day both conformed to the biological sample research requirement.