An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility.

Alexandra Madsen,Grit Höppner,Julia Krause,Marc N. Hirt,Sandra Laufer,Michaela Schweizer,Wilson Lek Wen Tan,Diogo Mosqueira,Chukwuemeka George Anene Nzelu,Ives Yubin Lim,Roger Foo,Thomas Eschenhagen,Justus Stenzig

An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility.

2020

Alexandra Madsen
Grit Höppner
Julia Krause
Marc N. Hirt
Sandra Laufer
Michaela Schweizer
Wilson Lek Wen Tan
Diogo Mosqueira
Chukwuemeka George Anene Nzelu
Ives Yubin Lim
Roger Foo
Thomas Eschenhagen
Justus Stenzig

Background: DNA methylation acts as a mechanism of gene transcription regulation. It has recently gained attention as a possible therapeutic target in cardiac hypertrophy and heart failure. However...

Keywords:

Heart failure
Medicine
Cell biology
DNA methylation
Metabolism
cardiac hypertrophy
Transcription (biology)
Contractility

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