Effect of preoperative peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on clinical prognosis of patients with lower-grade glioma
2019
Objective
To investigate the prognostic values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with lower-grade gliomas.
Methods
242 patients with pathological diagnosis of lower-grade gliomas (WHO Ⅱ and WHOⅢ) were enrolled in the study, and relevant data were collected. Kaplan-Meier method was used to calculate the survival rates. Cox regression model was used to conduct multivariate analysis.
Results
The best cut-off values for NLR and PLR were 1.95 and 197.22. The 3-year and 5-year survival rate for NLR≤1.95 and NLR>1.95 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P 197.22 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). High NLR (P<0.01) and PLR (P<0.05) were independent prognostic factors influencing the survival of lower-grade gliomas.
Conclusion
NLR and PLR were potential factors for predicting the survival of lower-grade gliomas.
Key words:
Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Lower-grade gliomas; Prognosis
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