Effect of preoperative peripheral blood neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on clinical prognosis of patients with lower-grade glioma

Objective To investigate the prognostic values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with lower-grade gliomas. Methods 242 patients with pathological diagnosis of lower-grade gliomas (WHO Ⅱ and WHOⅢ) were enrolled in the study, and relevant data were collected. Kaplan-Meier method was used to calculate the survival rates. Cox regression model was used to conduct multivariate analysis. Results The best cut-off values for NLR and PLR were 1.95 and 197.22. The 3-year and 5-year survival rate for NLR≤1.95 and NLR>1.95 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P 197.22 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). High NLR (P<0.01) and PLR (P<0.05) were independent prognostic factors influencing the survival of lower-grade gliomas. Conclusion NLR and PLR were potential factors for predicting the survival of lower-grade gliomas. Key words: Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Lower-grade gliomas; Prognosis