Evaluation of estradiol response to antiestrogen stimulation in fertile and oligozoospermic men reacting both positively and negatively to chronic treatment with clostilbegyt

: Antiestrogen stimulation test consisting in the administration of Clostilbegyt (50 mg dose twice daily during ten days) was performed in 21 normospermic fertile men, and in 36 patients with idiopathic oligozoospermia after chronic therapy with Clostilbegyt (50 mg daily for 240 days). Among the latter, in 24 the therapy did not bring improvement in the number of spermatozoa, and in 12 patients chronic treatment with Clostilbegyt resulted in about fivefold increase in the number of spermatocytes in 1 ml of semen. It was found that the increase in blood serum estradiol in response to stimulation was much higher (118.9%) in patients not reacting to chronic Clostilbegyt therapy than in normospermic subject (60.8%) or oligospermic patients who reacted positively to the therapy (58.8%). This observation suggests the mechanism of negative results of antiestrogenic therapy in the majority of oligozoospermic patients.