GENETIC MECHANISMS OF GROWTH DISORDERS IN PATIENTS WITH IDIOPATHIC SCOLIOSIS

Idiopathic scoliosis has been studied through centuries, but problems of its aetiology and pathogenesis up till now are the subjects of considerable discussion. Pathogenetic mechanism of the spine deformity development in idiopathic scoliosis (IS) was established on the basis of in-depth morphological and biochemical investigations of structural components of the spine in patients with IS (surgical material) (Zaidman A.M., et al. 2001). It was shown that IS develops on the basis of disturbance of proteoglycans (PG) synthesis and formation in vertebral growth plates. Decrease of chondroitin sulphate component of PG and increase of keratan sulphate one, as well as decrease in degree of sulphating of glycosaminoglycan (GAG) chains and increase of non-acetilated sugars – all this evidences for conformational changes in proteoglycans. The found keratan sulphate-related fraction is likely a marker of genetic changes in PGs in idiopathic scoliosis. Structural changes in PGs in combination with reduce of quantity...