Failure of testosterone and indomethacin to affect the LH response to synthetic LH-RH in normal men.

The luteinizing hormone (LH) response to synthetic LH-releasing hormone (RH) in 3 normal male subjects before and after 3 days of treatment with 100 and/or 4 days with 50 mg of indomethacin was evaluated. No appreciable difference exists between the LH responses before and after indomethacin treatment. A repetition of the treatment with 100 mg of indomethacin again brought no significant difference. These data though preliminary suggest that pituitary prostaglandins (PGs) are not likely to play an essential role in mediating LH-RH induced LH release in normal men. 2 possible factors of variation deserve further consideration: 1 is related to drug specificity for PG-synthetases of different tissues the other to possibly differential effects of the inhibitor on the ocnversion of dihomo-linoleic acid into PGE1 and PGF2alpha as compared with that of arachidonic acid into PGE2 and PGF2alpha.