Studies on hydroxyapatite applicatied in coprecipitate of total salvianolic acids phospholipid complex

The purpose of this research was to prepare total salvianolic acids-phytosome-HA coprecipitate to improve drug dissolution and its micromeritic properties. Firstly,the coprecipitate was prepared by solvent method and in vitro dissolution of tripterine was performed with the salvianolic acid B and danshensu as criteria. At the same time,the micromeritic properties was characterizated, the structure of samples was characterized by TEM,DSC,XRD and FTIR. Results showed that when the ratio of drug to HA was 1∶ 2,it had a better dissolution,the accumulative drug-release percent in vitro at 60 min was over 90%. At the same time,it has good liquidityand low moisture absorption. Its micromeritic properties have improved. It is proved that the drug still existed amorphously by microstructure analysis. The preparation process is simple and feasible,it has practical value.