Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis

Abstract Two new nucleoside derivatives, named asponguanosines A and B ( 1 and 2 ), three new N -acetyldopamine analogues, aspongamides C–E ( 3 – 5 ), one new sesquiterpene, aspongnoid D (6) , and three known compounds were isolated from the medicinal insect Aspongopus chinensis. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD and 13 C NMR calculations. Biological activities of compounds 3 – 7 towards human cancer cells, COX-2, ROCK1, and JAK3 were evaluated.