Effects on Anti-Aging Indicators in Middle-Aged Men of An Intervention to Prevent Lifestyle-Related Diseases

Objective: To-date, in middle-aged men the collection of data regarding the measurement of a wide range of health indicators, and the mutual relationships among these indicators, has been insufficient. Here, we evaluated from the viewpoint of anti-aging medicine, the effects on various anti-aging indicators in middle-aged men of a long-term intervention to prevent lifestyle-related diseases.Methods: Subjects were 18 male employees (mean age, 54.4 ± 7.4 years; mean body weight 77.5 ± 12.5 kg; mean BMI, 26.1 ± 3.6 kg/m2) of a machine manufacturer located in Kyoto City on whom a company-wide anti-aging medical checkup was performed. On the basis of the medical checkup results, exercise and nutritional instructions were given to the study subjects. In addition, subjects were lent pedometers and encouraged to walk, and the data recording the number of steps taken was collected once every four weeks. Anti-aging related indicators were measured before the study as well as 12 and 24 weeks thereafter. Muscle mass was measured with a body composition measuring device by bioelectrical impedance analysis (Physion MD), higher-brain functions were determined by the Wisconsin card sorting test (WCST), the degree of arteriosclerosis was evaluated by acceleration plethysmography (SDP-100), and bone mineral density was measured by ultrasonography (A-1000).(View PDF for the rest of the abstract.)