Применение препарата топирамат в комплексной терапии эпилепсии

Topiramate (Topamax®) is one of the most widely used modern anti-epileptic drugs (AED) in Russia. This is primarily due to the broad spectrum of activity of this drug. Its mechanism of action is complex and includes several components. It was shown that all main mechanisms of epilepsy development are within the pharmacological targets of this drug, which makes it distinguished among other AED. The drug is efficient in both focal and generalized forms of epilepsy. The following adverse effects of treatment may possibly develop: fatigability, thought disorder, headache and confused mental state. It should be borne in mind that the majority of adverse effects disappeared spontaneously in the course of treatment. Such adverse effects as reduction of body weight and nephrolithiasis generally occurred as long-term side effects of treatment.