Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model

Genomic imprinting is an epigenetic phenomenon that ensures the parental-specific expression of a subset of genes and is required for the normal mammalian development. Loss of genomic imprinting represents one of the most common genetic abnormalities in growth disorders and cancer. DNA methylation is a key component of genomic imprinting regulation in eutherian mammals, and most imprinted genes are associated with differentially methylated CpG-rich regions.