CHRONIC ITCH: EMERGING TREATMENTS FOLLOWING NEW RESEARCH CONCEPTS

Until recently, itch pathophysiology was poorly understood, and treatments were poorly effective in relieving itch. Current progress in knowledge on itch processing and the numerous mediators and receptors involved has led to a large variety of possible therapeutic pathways. Currently, anti-IL31, anti-IL4/13, anti-NK1, opioids, cannabinoids, anti-Jak, anti-phosphodiesterase-4, or anti-TRP are the main compounds in clinical trials. However, many expected, such as MRGPRs, and unexpected new pathways should also be explored.