1198 Treatment of localized Ewing's sarcoma in young adults. A study of the French society of pediatric oncology

From January 1988 to January 1992, 141 patients entered the EW88 protocol based on the chemotherapy (CT) used in St. Jude Hospital since 1978 (JCO 7, 208–213, 1989). Among them, 44 were young adults (15 to 35 yrs, median 20 yrs). Induction CT consisted in Cytoxan 150 mg/m 2 p.o. × 7 days followed by Adriamycin 35 mg/m 2 IV on day 8 for 5 courses beginning days 1, 15, 29, 50 and 71. Surgery was recommended whenever possible. Radiation was based upon the quality of surgery and the histological response to CT. Maintenance CT was based on vincristine + actinomycin and cytoxan + adriamycin. Total duration of therapy was 10 months. In March 1995, median follow-up of the cohort was 64 months (38–87 m). Outcome was similar in adults and children. 97 pts 44 pts ≥ 15 yrs no. pts without initial control 0 4 no. pts with local relapse 21 8 no. pts with isolated metastases 17 12 5year DFS 58% (± 10) 52% (± 15) N.S. 5 year Survival 64% (± 10) 65% (± 15) N.S.