Сочетанное применение лейтрагина и легочного сурфактанта-БЛ повышает выживаемость животных в модели фатального острого респираторного дистресс-синдрома

This study aims to investigate effects of leutragin — a stabilized analogue of the endogenous hexapeptide dynorphin 1-6 — in combination with pulmonary surfactant-BL on animal survival in an experimental fatal model of “cytokine storm” and acute respiratory distress syndrome (ARDS) in C57Bl/6Y mice. Compared to the control, administration of leutragin and pulmonary surfactant-BL in a combined regimen led to a statistically significant increase in the survival rate and a decrease in the risk of death in animals with ARDS. It was shown that the suppression of proinflammatory cytokine production in the lungs with a simultaneous replenishment of the endogenous surfactant with an exogenous pulmonary surfactant is a promising new pharmacological approach to the treatment of ARDS accompanied by a “cytokine storm”.