Method to treat dopaminergic and gaba-ergic disorders.

Use of a therapeutically effective amount of a hedgehog therapeutic agent for the manufacture of a medicament for the treatment or prevention of a disorder selected from the group consisting of ischemic lesion in the brain, stroke, cerebral ischemia and amyotrophic lateral sclerosis (ALS), where said hedgehog therapeutic agent comprises a polypeptide encoded by a nucleic acid that hybridizes under stringent conditions, including a washing step of 0.2 X SSC at 65 ° C, with a nucleic acid represented in any one of SEQ ID NO: 1-9.