Hypoxia in Human Gliomas: Demonstration by PET with Fluorine-18-Fluoromisonidazole

increased,with the two tissues reaching equality at 40—50 mm.Thetumor-to-plasma ratiowas0.71at 3 hr. Theother two patientsshowedvariabletumor retentionof [18F]fluorom isonidazole,with tumor-to-plasmaratios of 1.10 and 1.49 at 2 and3 hr.Theseresultsdemonstrate thefeasibility of using [18F]fluoromisonidazole PET to detect hypoxia in human gliomas invivo.Clinical trials areneeded todetermine whether a relationship existsbetween [18F]fluoromisonidazole uptake and tumor radiationresponse. JNucIMed 1992;33:2133—2137