Influence of β-CD and Its Derivatives on Solubilization and Fluoresence Enhancement of Curcumin

The influence of β-CD,HP-β-CD and different displaced cyclodextrin sulfates (2-β-CDS,6-β-CDS,random displaced β-CDS) on solubilization and fluorescence enhancement of curcumin was discussed. The fluorophotometric titration method was used to determine the complex stability constants (K) for the inclusion complexation of curcumin and five cyclodextrins in buffer solution (pH 2). The results showed that 1∶1 inclusion complexation was observed in β-CD with curcumin,while 2∶1 and 1∶1 inclusion complexations were observed in HP-β-CD and cyclodextrin sulfates with curcumin. HP-β-CD and β-CDS showed better complexation ability,and fluorescence was enhanced by 17 and 19 times in 0.03mol/L concentrations.