Fusion protein for inducing peripheral blood mononuclear cells to produce tuberculosis specific cytokines

The invention discloses fusion protein for inducing peripheral blood mononuclear cells to produce tuberculosis specific cytokines. The fusion protein includes CFP-10 protein, ESAT-6 protein and EspC protein which are connected through connecting peptides. Compared with an existing stimulus, the fusion protein is more efficient in effect, higher in sensitivity, higher in specificity and good in stimulating effect. Meanwhile, the fusion protein stimulates PBMC to produce lots of tuberculosis related factors such as IFN-gamma, IL-2 and TNF-alpha with mycobacterium tuberculosis antigenic specificity, and the stimulus-induced reaction is not interfered with by bacillus calmette guerin vaccine. By means of the fusion protein, the relevance ratio of tuberculosis is more effectively improved, and the fusion protein has positive significance in control over tuberculosis. The fusion protein as a stimulus can be applied to research on a tuberculosis pathopoiesia and immunity prevention mechanism and further control over tuberculosis.