Early diagnosis of cancers using fluorescence imaging of tissues

The imaging system we have developed for early cancers detection, acquires and displays in real time, two different spectral images representing the same site excited alternately with an Argon laser and a Xenon lamp. A step by step engine and an optical system are used to alternate and focalize the two excitation lights through the endoscope optical canal. Image acquisition proceeded via a high pass filtered camera, is synchronized with excitation lights thanks to signals exchange between four electronic boards. Inter-image processing is performed to eliminate undesirable information. In-vivo fluorescence images showing bladder's lesions more contrasted than white lighted ones, have been obtained with a previous version of this system. The first results of the final system were achieved on phantoms simulating healthy and cancerous tissues.