Clinical study and survival analysis of combined modality therapies for advanced hypopharyngeal carcinoma

Objective:To evaluate the efficacy of combined modality therapy for advanced hypopharyngeal carcinoma in order to improve the curative effect of hypopharyngeal carcinoma.Method:Seventy-six male patients with the stage Ⅲ-Ⅳ hypopharyngeal carcinoma were treated with postoperative combined modality.Of all the 76 cases,44 were treated with postoperative radiotherapy,and the other 32 treated with chemoradiotherapy concurrently.Result:Kaplan Meier analysis indicated that the overall 5 survival rates of patients treated with postoperative radiotherapy was 25.9%,and that of patients treated with postoperative chemoradiotherapy was 27.8%.There was no significant difference between the two groups(P0.05).Three and five years relapse-free survival rates of the patients treated with postoperative radiotherapy were 36.0%,22.5%,and those of the patients treated with postoperative chemoradiogtherapy were 68.0%,45.3%.Significant difference was calculated between the two groups(P0.05).According to the NCI CTC3.0 criteria,the toxicities on grade 3 or above of the two groups showed no significant difference(P0.05).Conclusion:For advanced hypopharyngeal carcinoma,postoperative chemoradiotherapy yielded satisfactory relapse free survival and laryngeal function preservation rate which was superior to that of postoperative radiotherapy.Also the treatment toxicities were not increased.