The effect of staphylococcal antigen on the output of cells from the popliteal lymph node of immunized sheep

Abstract Extract It has been recorded that, following the injection of antigen, there is a transient fall in the number of lymphocytes in the lymphleaving the popliteal lymph node draining the injection site (Hall and Morris, 1962, 1965). This is followed by a rise in the number of lymphocytes in the efferent lymph and the appearance of polymorphonuclear neutrophils. Subsequently, as part of the immune response, cells of the plasmacytic series appear in the lymph (Hall and Morris, 1963; Cunningham et al., 1966). In addition, these workers have shown that these changes occur only in the node draining the site of antigen injection and not in the contralateral node, thus indicating a local reaction.