A Family Based Study of Carbon Monoxide and Nitric Oxide Signalling Genes and Preeclampsia

Background Preeclampsia is thought to originate during placentation, with incomplete remodeling and perfusion of the spiral arteries leading to reduced placental vascular capacity. Nitric oxide (NO) and carbon monoxide (CO) are powerful vasodilators that play a role in the placental vascular system. Although family clustering of preeclampsia has been observed, the existing genetic literature is limited by a failure to consider both mother and child.