Design, synthesis and bioassay of novel metal complexes of 3-amino-2-methylquinazolin-4(3H)-one

New ligand 3-amino-2-methylquinazolin-4(3H)-one (L) has been synthesized in good yield by the reaction of anthranilic acid with acetic anhydride then replaced the oxygen with nitrogen of hydrazine. When the ligand react with Co(II), Ni(II) and Cu(II) new complexes are formed. The chemical structure of all prepared compounds were characterized by FT-IR, elemental analysis, 1 H-NNR and UV/visible spectra, moreover determination of molar ratio M:L, molar conductance in D.M.F solution, magnetic moments (�eff.) and determination of metal content M% by flame atomic absorption spectroscopy. The free ligand and their metal complexes have been tested in vitro against a number of microorganisms (gram positive bacteria (Staphylococcus aureus and Bacillus cereus) and gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus vulgaris)) in order to assess their antimicrobial properties. All our complexes showed considerable activity against all bacteria.