Determinanten von Digoxin-und Digitoxinplasmakonzentrationen bei älteren Patienten

In 1063 patients (≥60 years, 531 men, 532 women) the plasma concentration during digitalis maintenance therapy (metildigoxin, n=356, beta-acetyldigoxin, n=359, and digitoxin, n=348) was determined and related to sex, age, body weight, serum potassium, renal function and the prescribed daily maintenance dose. Classification of treatment groups according to renal function (Crea ≤1.3 mg/dl//> 1.3 mg/dl) did not show any difference of the mean maintenance doses.