Derivatives of 4- (phenylamino) -6-oxo-1,6-3-carboxamide as MEK inhibitors for the treatment of hyperproliferative diseases.

2006 
A compound having Formula I ** ** see formula or a pharmaceutically acceptable salt thereof wherein: ** ** see formula R1 is Cl or F; R3 is H, Me, Et, OH, MeO-, EtO-, HOCH2CH2O-, HOCH2C (Me) 2O (S) -MeCH (OH) CH2O-, (R) -HOCH2CH (OH) CH2O-, cyclopropyl CH2O-, HOCH2CH2-, R7 is cyclopropyl-CH2- or C1-C4 alkyl, wherein said alkyl is optionally substituted with one or more F; R8 is Br, I or SMe; and R9 is CH3, CH2F, CHF2, CF3, F or Cl.
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