Preparation and application of high-molecular vesicle hydrogel drug carrier

2016 
The invention discloses preparation and application of a high-molecular vesicle hydrogel drug carrier. The preparation method comprises the following steps of preparing a high-molecular polymer solution, preparing a high-molecular vesicle solution, preparing high-molecular vesicle composite hydrogel and loading a drug into the high-molecular vesicle composite hydrogel. According to the preparation and application of the high-molecular vesicle hydrogel drug carrier, a macromolecule and monomer pair method is used for assembling high-molecular vesicles, the assembled high-molecular vesicles are composed of two parts, the first part is biomacromolecules with sulfonate radicals and carboxylate radicals, and the second part is poly(2-(diethylamino)ethyl methacrylate) with tertiary amino; an aqueous solution containing the high-molecular vesicles is mixed with hydroxyethyl methacrylate monomers, a photoinitiator I2959 is added for initiated polymerization, the composite hydrogel drug carrier is formed, and the drug is loaded into the hydrogel drug carrier in an adsorption mode. Meanwhile, the invention discloses application of the high-molecular vesicle hydrogel drug carrier in medicament for the eyes, and good drug controlled-release capacity is embodied.
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