Therapeutic effect of ultrasound interventional perirenal catheter-assisted early peripancreatic lavage of protease inhibitor on severe acute pancreatitis in miniature pigs

Abstract Objectives To study the therapeutic effect of early peripancreatic lavage of ulinastatin on severe acute pancreatitis(SAP). Methods Sixteen pigs were divided into 4 groups: model(SAP), saline lavage(SL), ulinastatin lavage(UL), intravenous ulinastatin(IU). UL and SL group were given peripancreatic lavage of ulinastatin by ultrasound-guided perirenal catheterization and IU group was intravenously instilled with ulinastatin. The multi-organ functions and the inflammatory factors were observed. Results UL group has the best therapeutic effect. The changes of multi-organ functions and the inflammatory factors were compared with SAP group as follows. In time window of treatment: amylase (p   0.05), AST (p   0.05), IL-6 (p  Conclusions Early peripancreatic lavage of ulinastatin in SAP could effectively improve the multi-organ functions and inflammatory response.