A novel RNA synthetic method with a 2′-O-(2-cyanoethoxymethyl) protecting group
2006
A novel method for the synthesis of RNA oligomers with 2-cyanoethoxymethyl (CEM) as the 2‘-hydroxyl protecting group has been developed. The new method allows the synthesis of oligoribonucleotides with an efficiency and final purity comparable to that obtained in DNA synthesis.
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