Synthesis and stability study of the new pentammonio lipid pcTG90, a gene transfer agent

Abstract The cationic lipid pcTG90 has been prepared from ( S )-1-aminopropane-2,3-diol by N -acylation with N -protected 18-amino-3,7,11,15-tetraazaoctadecanoic acid and O -acylation with oleic acid. The former acid could be obtained from 1,3-propanediamine via tetraprotected caldopentamine. The stability of the cationic lipid in HEPES buffer has been studied.