mTOR regulates TGF-β2-induced epithelial–mesenchymal transition in cultured human lens epithelial cells

Background Post-cataract surgery fibrosis in the lens capsule is caused by epithelial to mesenchymal transition (EMT) of the lens epithelium. Mammalian target of rapamycin (mTOR) has been demonstrated to be a key regulator of EMT. The aim of this study was to investigate the role of mTOR in transforming growth factor β2 (TGF-β2)-induced EMT in human lens epithelial cells (HLECs).