Sulfonylureas Stimulate Glucose Uptake through GLUT4 Transporter Translocation in Rat Skeletal Muscle

Abstract We studied the effect of gliclazide on glucose uptake and GLUT4 translocation in skeletal muscle. Rat hindquarters were perfused in the absence or presence of gliclazide (300 μg/ml), insulin or both drugs. The basal glucose uptake was increased 2.7-fold by gliclazide (p